Balfour is a town situated along the R351 Regional Route to Katberg in the Eastern Cape province of South Africa.
The town is part of the Raymond Mhlaba Local Municipality in the Amathole District of the Eastern Cape province.
The town, which lies at the foot of the Katberg, was established as a mission station of the Glasgow Missionary Society in 1828 by John Ross and McDiarmid, and named after Robert Balfour, the first secretary of the society.
Throughout the nine Frontier Wars, the town experienced some heavy fighting. Today, tobacco, citrus, wool and beef farming are practised in the area.
Balfour should not be confused with another town (Balfour, Mpumalanga) of a similar name in the Mpumalanga province of South Africa.